{"Abbreviation":[],"Absorption, Distribution and Excretion":"Following oral inhalation of 320 mcg of beclomethasone dipropionate (BDP), the Cmax was 88 pg/mL and it was reached after 0.5 at post-administration. The mean Cmax of the major and most active metabolite, beclomethasone-17-monopropionate (17-BMP), was 1419 pg/mL at 0.7 hour post-dosing.  In another pharmacokinetic study, the AUC of BDP and 17-BMP were 6660 and 6185 pgxh/mL, respectively. The Cmax was 35356 pg/mL for BDP and 2633 pg/mL for 17-BMP, and and the median time to reach these concentrations (Tmax) was 0.2 hours. In the same study, the AUC of 17-BMP following oral and intranasal administration were 10158 and 3660 pgxh/mL, respectively. The Cmax of 17-BMP following oral and intranasal administration were 703 and 310 pg/mL, respectively, and the Tmax was 4 hours. The total bioavailability of 17-BMP following oral and intranasal administration were 41% and 44%, respectively.","Biological Half-Life":"Following intravenous administration, the half life of beclomethasone dipropionate was 0.5 hours while the half life of the active metabolite 17-BMP was 2.7 hours. Following oral and intranasal administration, the half life of 17-BMP was 8.8 and 5.7 hours, respectively.","CAS":"5534-09-8","ChemicalClasses":["steroid"],"Chirality":"absolute","Drug Indication":"Indicated for oral inhalation use in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older. The aerosol form of beclomethasone diproprionate is not indicated for the relief of acute bronchospasm.  Indicated for intranasal use to relieve the symptoms of seasonal or perennial allergic and nonallergic (vasomotor) rhinitis and prevent the recurrence of nasal polyps following surgical removal.  Indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 13 years of age and older. Corticosteroid-responsive dermatoses include psoriasis, contact dermatitis (dermatitis venenata), atopic dermatitis (infantile eczema, allergic dermatitis), neurodermatitis (lichen simplex chronicus, lichen planus, eczema, eczematous dermatitis), intertrigo, dyshidroses (pompholyx), seborrheic dermatitis, exfoliative dermatitis, solar dermatitis, stasis dermatitis, and anogenital and senile pruritus.","DurationOfAction":"","EliminationHalfLife":"","Esters":[],"European Community (EC) Number":"226-886-0","FDA Pharmacological Classification":"BECLOMETHASONE DIPROPIONATE","Formating":[],"HMDB ID":"HMDB0014538","HeavyAtomCount":36,"Human Drugs":"Human drug -\u003e Discontinued","IUPACName":"[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate","InChI":"InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1","InChIKey":"KUVIULQEHSCUHY-XYWKZLDCSA-N","KEGG Entries":[{"Id":"D00689","Interactions":[{"Action":"inhibition","Target":"CYP3A4"},{"Action":"induction","Target":"CYP3A4"},{"Action":"inhibitioninduction","Target":"CYP3A4"}],"Synonyms":["Beclomethasone dipropionate","Beclometasone dipropionate","Beclovent","Qnasl","Vanceril"]}],"MeSH Pharmacological Classification":"Substances that reduce or suppress INFLAMMATION.","Mechanism of Action":"Beclomethasone dipropionate is a corticosteroid and prodrug that is rapidly activated by hydrolysis to the active monoester, 17 monopropionate (17-BMP), which mediates anti-inflammatory actions. 17-BMP has been shown _in vitro_ to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 13 times that of dexamethasone and 25 times that of beclomethasone dipropionate. Upon binding of the ligand, the glucocorticoid receptors dimerize and translocate into the nucleus, where they subsequently bind to glucocorticoid response elements (GRE) on glucocorticoid-responsive genes, leading to changes in transcription. There are several proposed mechanisms for the anti-inflammatory action of corticosteroids. Corticosteroids may work by increasing the transcription of genes coding for anti-inflammatory proteins, including lipocortin-1 and interleukin-10. Corticosteroids were also shown to inhibit the expression of multiple genes that encode pro-inflammatory factors, such as cytokines, chemokines, and adhesion molecules, that are activated during the chronic inflammatory process. This is thought to be due to the direct inhibitory interaction between activated glucocorticoid receptors and activated pro-inflammatory transcription factors, such as nuclear factor-kappa B and activator protein-1. Chronic inflammation is often characterized by enhanced expression of these transcription factors that bind to and activate coactivator molecules, which then acetylate core histones to switch on gene transcription to further amplify the inflammatory process. Corticosteroids suppress the multiple inflammatory gene expression by promoting histone deacetylation, resulting in tighter coiling of DNA and reduced access of transcription factors to their binding sites.","Melting Point":"208-210","Metabolism/Metabolites":"During absorption, beclomethasone dipropionate is undergoes rapid and extensive hydrolysis mediated by esterases CYP3A to form beclomethasone-17-monopropionate (17-BMP), beclomethasone-21-monopropionate (21-BMP), and beclomethasone (BOH). 17-BMP is the major active metabolite with the most potent anti-inflammatory activity. About 95% of the total beclomethasone dipropionate administered via oral inhalation undergoes presystemic conversion to form 17-BMP in the lung.","MolecularFormula":"C\u003csub\u003e28\u003c/sub\u003eH\u003csub\u003e37\u003c/sub\u003eClO\u003csub\u003e7\u003c/sub\u003e","MolecularWeight":"521.0 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Inflammatory conditions, including asthma, dermatoses, and allergic rhinitis, involve the activation of cascades by inflammatory mediators. Inflammation is a primary defense mechanism and the homeostatic response of the immune system; however, a prolonged inflammatory response in certain disorders may lead to tissue damage, pain, and swelling. Beclomethasone dipropionate works by attenuating the inflammatory responses associated with asthma, allergic rhinitis, nasal polyps, and corticosteroid-responsive dermatoses. It suppresses the actions of inflammatory cells, such as mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils. It also inhibits the release of inflammatory mediators, such as histamine, eicosanoids, leukotrienes, and cytokines. Beclomethasone dipropionate is reported to exhibit potent topical activity while possessing low systemic effects.   Beclomethasone dipropionate is a corticosteroid drug with anti-inflammatory and vasoconstrictive effects used to treat chronic inflammatory processes such as asthma, allergic rhinitis, corticosteroid-responsive dermatoses. When inhaled, it improves lung function, decreases airway hyper-reactivity, and reduces the severity of asthmatic symptoms. Although inhaled corticosteroids, including beclomethasone dipropionate, are reported to mainly act locally in the lungs, systemic effects such as disruption of hypothalamic-pituitary-adrenal (HPA) axis function, bone turnover, osteoporosis, and growth suppression may still be observed with chronic use or high dose administration. There were varying findings from clinical studies examining the effect of beclomethasone dipropionate on growth suppression in pediatric patients. It was shown to suppress the hypothalamo-pituitary-adrenal (HPA) axis in a dose-dependent manner. HPA axis is a central hormonal response system to stress and activation of HPA axis leads to the production of endogenous steroid hormone production. Long-term use of high-dose systemic corticosteroids, including those inhaled, was often associated with signs and symptoms of adrenal insufficiency when exposed to stress conditions, such as trauma, surgery, or infections. As corticosteroids work by suppressing the immune system, there may be an increased risk for developing infections. Cases of _Candida albicans_ infection of the mouth and throat have been reported with inhaled beclomethasone dipropionate therapy.","Physical Description":"Solid","PubChemId":21700,"Records":{"UNII":{"Impurities":["beclomethasone 17-monopropionate","beclomethasone 21-acetate 17-propionate","9-deschloro-9-bromo-beclomethasone dipropionate","1,2-dihydro-beclomethasone dipropionate","betamethasone 9,11-epoxide","2-bromo-beclomethasone dipropionate","16.beta.-methyl-3,20-dioxopregna-1,4,9(11)-triene-17,21-diyl dipropanoate","6.alpha.-chloro-beclomethasone dipropionate","betamethasone 9,11-epoxide 17,21-dipropionate","16.beta.-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate","beclomethasone dipropionate 11-propionate","beclomethasone 21-butyrate 17-propionate","9-chloro-11.beta.-hydroxy-16.beta.-methyl-3,20-dioxopregna-4,6-diene-17,21-diyl dipropanoate","9,11.beta.-dichloro-16.beta.-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate","6.alpha.-bromo-beclomethasone dipropionate","betamethasone 9,11-epoxide 17-propionate","betamethasone 9,11-epoxide 21-propionate"]}},"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Beclometasone","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q421475","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00394","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/21700","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=5534-09-8","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014538","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07813","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/5B307S63B2","Name":"Beclometasone dipropionate","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3048730","Name":"Beclometasone dipropionate","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 21700, Beclomethasone Dipropionate. Accessed December 22, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/21700\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/21700\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Beclometasone dipropionate. UNII: 5B307S63B2. Global Substance Registration System. Accessed December 22, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5B307S63B2\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/5B307S63B2\u003c/a\u003e","Therapeutic Goods (Poisons Standard— June 2025) Instrument 2025. May 1, 2025. Accessed December 22, 2025. \u003ca href=https://www.legislation.gov.au/F2025L00599/asmade/2025-05-28/text/original/pdf\u003ehttps://www.legislation.gov.au/F2025L00599/asmade/2025-05-28/text/original/pdf\u003c/a\u003e"],"SMILES":"CCC(=O)OCC(=O)[C@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)Cl)O)C)C)OC(=O)CC","SaltData":[{"AcidCount":1,"Amine":"Beclometasone dipropionate","AmineCount":1,"Formula":"O","Name":"monohydrate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 176.83 107.154\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h177v108H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m149.276 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